Product Name :
NCGC00247743
Description:
NCGC00247743 is a histone lysine demethylase KDM4 inhibitor.
CAS:
1435192-04-3
Molecular Weight:
391.51
Formula:
C24H29N3O2
Chemical Name:
N-[6-(dimethylamino)hexyl]-3-(8-hydroxyquinolin-6-yl)benzamide
Smiles :
CN(C)CCCCCCNC(=O)C1C=C(C=CC=1)C1C=C2C=CC=NC2=C(O)C=1
InChiKey:
RAUALYDCIUPMKI-UHFFFAOYSA-N
InChi :
InChI=1S/C24H29N3O2/c1-27(2)14-6-4-3-5-12-26-24(29)20-10-7-9-18(15-20)21-16-19-11-8-13-25-23(19)22(28)17-21/h7-11,13,15-17,28H,3-6,12,14H2,1-2H3,(H,26,29)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
NCGC00247743 is a histone lysine demethylase KDM4 inhibitor.|Product information|CAS Number: 1435192-04-3|Molecular Weight: 391.51|Formula: C24H29N3O2|Chemical Name: N-[6-(dimethylamino)hexyl]-3-(8-hydroxyquinolin-6-yl)benzamide|Smiles: CN(C)CCCCCCNC(=O)C1C=C(C=CC=1)C1C=C2C=CC=NC2=C(O)C=1|InChiKey: RAUALYDCIUPMKI-UHFFFAOYSA-N|InChi: InChI=1S/C24H29N3O2/c1-27(2)14-6-4-3-5-12-26-24(29)20-10-7-9-18(15-20)21-16-19-11-8-13-25-23(19)22(28)17-21/h7-11,13,15-17,28H,3-6,12,14H2,1-2H3,(H,26,29)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 62.5 mg/mL (159.64 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Doxycycline hyclate site |Shelf Life: ≥12 months if stored properly.Hispidin Metabolic Enzyme/Protease |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Based on structure-activity relationship studies, a series of chemical compounds are derived from 8-hydroxyquinoline (8HQ) and shown to be active inhibitors of KDM4E and KDM4A.PMID:32967484 The effect of these compounds is tested on the growth of LNCaP cells and NCGC00247751 (A1), NCGC00244536 (B3), and NCGC00247743 (I9) are selected. These inhibitors inhibit LNCaP cell growth with IC50s in the μM range. These compounds also inhibit the enzymatic activity of other KDM4 isoforms although, interestingly, the potency and efficacy of B3 and A1 for KDM4A, 4C, and 4D are lower compared to that of NCGC00247743 (I9), suggesting a potential selectivity of the inhibitors for different isoforms of KDM4.|Products are for research use only. Not for human use.|
