Name :
CDK4/CCND3 (Human) Recombinant Protein
Biological Activity :
Human CDK4 (NM_000075, 4 a.a. – 303 a.a.) and CCND3 (NM_001760, 1 a.a. – 292 a.a.) Recombinant protein with His tag expressed in Sf9 cells.Bioactive Protein,Bioactive Proteins,Bioactive,Active,Functional Protein,Functional Proteins
Tag :
Result of activity analysis
Protein Accession No. :
NM_000075 (Gene ID : 1019);NM_001760 (Gene ID : 896)
Protein Accession No.URL :
https://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=896
Amino Acid Sequence :
Molecular Weight :
CDK4: 59.700 , CCND3
Storage and Stability :
Store at -80°C.Aliquot to avoid repeated freezing and thawing
Host :
insect
Interspecies Antigen Sequence :
Preparation Method :
Insect cell (Sf9) expression system
Purification :
One-step affinity purification using GSH-agarose
Quality Control Testing :
2 ug/lane SDS-PAGE Stained with Coomassie Blue
Storage Buffer :
In 50 mM Tris-HCl, 100 mM NaCl, pH 8.0. (5 mM DTT, 4 mM reduced glutathione, 20% glycerol)
Applications :
Functional Study， SDS-PAGE，
Gene Name :
CCND3
Gene Alias :
–
Gene Description :
cyclin D3
Gene Summary :
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations :
D3-type cyclin|G1/S-specific cyclin D3|OTTHUMP00000016390
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