Cynomolgus IGF1R/CD221 Protein 5056

Additional Information:
accession G7P9I7|express systemHEK293|product tagC-His|purity> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC|backgroundThe type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target.|molecular weightThe protein has a predicted MW of 80.59 kDa (alpha subunit) and 19.28 kDa (beta subunit). Due to glycosylation, the protein migrates to 48-58 kDa (beta subunit) and 100-115 kDa (alpha subunit) and 130-150 kDa based on Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Cynomolgus IGF1R/CD221 Protein 5056proteinSize and concentration100, 500g and lyophilizedFormLyophilizedStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped at ambient temperature.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceThe type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target.Protein namesTyrosine-protein kinase receptor (EC 2.7.10.1)Gene namesIGF1R,IGF1RProtein familyProtein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamilyMass9541DaCatalytic activityBINDING 985; /ligand=”ATP”; /ligand_id=”ChEBI:CHEBI:30616″; /evidence=”ECO:0000256|PIRSR:PIRSR000620-2″; BINDING 1009; /ligand=”ATP”; /ligand_id=”ChEBI:CHEBI:30616″; /evidence=”ECO:0000256|PIRSR:PIRSR000620-2, ECO:0000256|PROSITE-ProRule:PRU10141″; BINDING 1056..1062; /ligand=”ATP”; /ligand_id=”ChEBI:CHEBI:30616″; /evidence=”ECO:0000256|PIRSR:PIRSR000620-2″; BINDING 1115..1116; /ligand=”ATP”; /ligand_id=”ChEBI:CHEBI:30616″; /evidence=”ECO:0000256|PIRSR:PIRSR000620-2″; BINDING 1129; /ligand=”ATP”; /ligand_id=”ChEBI:CHEBI:30616″; /evidence=”ECO:0000256|PIRSR:PIRSR000620-2″Subellular locationMembrane ; Single-pass type I membrane protein .Target Relevance information above includes information from UniProt accession: G7P9I7The UniProt Consortium|