The lifespan of most cells in biological organisms is limited, and typically the organism’s life expectancy far exceeds this cellular limit. Continuous cell loss necessitates mechanisms to replenish the cell…
A 47-year-old Egyptian man with a history of hepatitis C-related cirrhosis was admitted to our hospital in July 2012 presenting with progressive ascites, jaundice, hepatic encephalopathy, and fever. He had…
Cadmium (Cd), a highly toxic heavy metal, has become a significant environmental contaminant due to industrial activities and pollution from mining, electroplating, and waste disposal. Its persistence in ecosystems and…
**Background** Prostanoids are a group of lipid mediators derived from arachidonic acid that play critical roles in regulating various physiological processes, including inflammation, blood flow, and vascular tone. Among these,…
UTL-5g is a novel small-molecule chemoprotector that mitigates cisplatin-induced hepatotoxicity, nephrotoxicity, and myelotoxicity primarily through inhibition of tumor necrosis factor-alpha (TNF-α). To better understand its metabolic fate, this study aimed…
**Background** The succinate receptor, also known as SUCNR1 or GPR91, is a G protein-coupled receptor that plays a critical role in sensing succinate levels, which often increase during metabolic stress,…
Varicella zoster virus (VZV) is a neurotropic alphaherpesvirus responsible for chickenpox and herpes zoster in humans. Despite advances in vaccination, the incidence of shingles remains significant, particularly among older or…
**Background** Chronic obstructive pulmonary disease (COPD) and asthma are prevalent inflammatory airway diseases characterized by the infiltration of inflammatory cells, particularly neutrophils, into the lung parenchyma. The recruitment of these…
Cryptococcus neoformans remains a significant cause of morbidity and mortality, particularly in immunocompromised individuals. This fungal pathogen is notorious for causing life-threatening meningitis, especially among HIV-positive patients in sub-Saharan Africa,…
**Background** Hepatocellular carcinoma (HCC) remains a global health challenge characterized by rapid proliferation and high recurrence rates. The development of effective therapeutic agents often focuses on modulating the cell cycle…