December 2016

This finding has strengthened the hypothesis that CLL BCRs may frequently, if not generally, recognize molecular binding motifs on apoptotic cells, also taking into account reactivities with other proteins exposed on apoptotic cell surfaces

Vimentin has been explained as an antigen identified by diverse stereotyped (IGHV3-thirty-subset 32 , IGHV4-39-subset 8 ) and nonstereotyped (IGHV3-thirty ) CLL BCRs. This obtaining has strengthened the hypothesis that…