Product Name :
BAY-8002
Description:
BAY-8002 is a potent, selective, orally active inhibitor of monocarboxylate transporter 1 (MCT1), with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4. Anti-tumor activity.
CAS:
724440-27-1
Molecular Weight:
415.85
Formula:
C20H14ClNO5S
Chemical Name:
2-[5-(benzenesulfonyl)-2-chlorobenzamido]benzoic acid
Smiles :
OC(=O)C1=CC=CC=C1NC(=O)C1=CC(=CC=C1Cl)S(=O)(=O)C1C=CC=CC=1
InChiKey:
CLAUJSRBKSRTGQ-UHFFFAOYSA-N
InChi :
InChI=1S/C20H14ClNO5S/c21-17-11-10-14(28(26,27)13-6-2-1-3-7-13)12-16(17)19(23)22-18-9-5-4-8-15(18)20(24)25/h1-12H,(H,22,23)(H,24,25)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
BAY-8002 is a potent, selective, orally active inhibitor of monocarboxylate transporter 1 (MCT1), with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4. Anti-tumor activity.|Product information|CAS Number: 724440-27-1|Molecular Weight: 415.85|Formula: C20H14ClNO5S|Chemical Name: 2-[5-(benzenesulfonyl)-2-chlorobenzamido]benzoic acid|Smiles: OC(=O)C1=CC=CC=C1NC(=O)C1=CC(=CC=C1Cl)S(=O)(=O)C1C=CC=CC=1|InChiKey: CLAUJSRBKSRTGQ-UHFFFAOYSA-N|InChi: InChI=1S/C20H14ClNO5S/c21-17-11-10-14(28(26,27)13-6-2-1-3-7-13)12-16(17)19(23)22-18-9-5-4-8-15(18)20(24)25/h1-12H,(H,22,23)(H,24,25)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (300.β-Muricholic acid custom synthesis 59 mM; Need ultrasonic).Tedizolid Epigenetic Reader Domain |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:35149831 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|BAY-8002 is an inhibitor of MCT1, with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4 (IC50 >50 µM in EVSA-T cells).|In Vivo:|BAY-8002 (80 and 160 mg/kg, p.o., twice daily, for more than 26 days) significantly inhibits tumor growth in Raji tumor-bearing mice.|Products are for research use only. Not for human use.|
