Product Name :
Edasalonexent
Description:
Edasalonexent (CAT-1004) is an orally bioavailable NF-κB inhibitor.
CAS:
1204317-86-1
Molecular Weight:
490.68
Formula:
C31H42N2O3
Chemical Name:
(4Z,7Z,10Z,13Z,16Z,19Z)-N-2-[(2-hydroxyphenyl)formamido]ethyldocosa-4,7,10,13,16,19-hexaenamide
Smiles :
CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)NCCNC(=O)C1=CC=CC=C1O
InChiKey:
JQLBBYLGWHUHRW-KUBAVDMBSA-N
InChi :
InChI=1S/C31H42N2O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25-30(35)32-26-27-33-31(36)28-23-21-22-24-29(28)34/h3-4,6-7,9-10,12-13,15-16,18-19,21-24,34H,2,5,8,11,14,17,20,25-27H2,1H3,(H,32,35)(H,33,36)/b4-3-,7-6-,10-9-,13-12-,16-15-,19-18-
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Isoniazid Mitophagy
Additional information:
Edasalonexent (CAT-1004) is an orally bioavailable NF-κB inhibitor.|Product information|CAS Number: 1204317-86-1|Molecular Weight: 490.68|Formula: C31H42N2O3|Chemical Name: (4Z,7Z,10Z,13Z,16Z,19Z)-N-2-[(2-hydroxyphenyl)formamido]ethyldocosa-4,7,10,13,16,19-hexaenamide|Smiles: CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)NCCNC(=O)C1=CC=CC=C1O|InChiKey: JQLBBYLGWHUHRW-KUBAVDMBSA-N|InChi: InChI=1S/C31H42N2O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25-30(35)32-26-27-33-31(36)28-23-21-22-24-29(28)34/h3-4,6-7,9-10,12-13,15-16,18-19,21-24,34H,2,5,8,11,14,17,20,25-27H2,1H3,(H,32,35)(H,33,36)/b4-3-,7-6-,10-9-,13-12-,16-15-,19-18-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 120 mg/mL (244.56 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.Chamaejasmenin A manufacturer |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Edasalonexent is an orally administered small molecule in which salicylic acid and docosahexaenoic acid (DHA) are covalently conjugated through an ethylenediamine linker and that is designed to synergistically leverage the ability of both of these compounds to inhibit NF-κB.PMID:35126175 Edasalonexent significantly inhibits NF-κB p65-dependent inflammatory responses as well as downstream proinflammatory genes modulated by p65 in the golden retriever duchenne muscular dystrophy (DMD) model.|In Vivo:|The treatment of mdx mice with Edasalonexent for 20 weeks results in reduced susceptibility of the extensor digitorum longus muscle to eccentric contraction-induced injury.|Products are for research use only. Not for human use.|
