Ke_TB, ke_Vtg, lLH, lLH, lLH, lLH, lVTG, lVTG, lVTG
Ke_TB, ke_Vtg, lLH, lLH, lLH, lLH, lVTG, lVTG, lVTG, lVTG, lEE2, lEE2, lEE2, lEE2,othothothbrngonlivothbrngonlivothbldbrnPage 10 ofgonTeeguarden and Barton [36] Watanabe et al. [20]livTable 1 Model parameters treated as constants (n = 97) (Continued)Partition coefficient of EE2 (“other” to blood) Partition coefficient of E2 (blood to water) Partition coefficient of E2 (brain to blood) Partition coefficient of E2 (gonad to blood) Partition coefficient of E2 (liver to blood) Partition coefficient of E2 (“other” to blood) Partition coefficient of T (brain to blood) Partition coefficient of T (gonad to blood) Partition coefficient of T (liver to blood) Partition coefficient of T (“other” to blood) Partition coefficient of TB (brain to blood) Partition coefficient of TB (gonad to blood) Partition coefficient of TB (liver to blood) Partition coefficient of TB (“other” to blood)a bLi et al. BMC Systems Biology 2011, 5:63 http://www.biomedcentral.com/1752-0509/5/lEE2, lE2, lE2, lE2, lE2, lE2, lT, lT, lT, lT, lTB, lTB, lTB, lTB,oth1 300 1 1 3 1 1 1 1 1 1 1 1Teeguarden and Barton [36] Watanabe et al. [20] Teeguarden and Barton [36] Plowchalk and Teeguarden [60] Watanabe et al. [20] Plowchalk and Teeguarden [60] Barton and Andersen [69] Barton and Andersen [69] Barton and Andersen [69] Barton and Andersen [69] Barton and PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28914615 Andersen [69] Barton and Andersen [69] Barton and Andersen [69] Barton and Andersen [69]bldbrngonlivothbrngonlivothbrngonlivoth, , andcwere assigned with measured values in each fish; the default values were used only when measured data were missing.Page 11 ofTable 2 Summary statistics for prior and posterior distributions of calibrated model parameters (n = 26)Parameter description Symbols Prior Distribution (P1, P2)a Loguniform (1, 1.0E+3) Lognormal (8.6, 3) Lognormal (1.66, 3) Lognormal (6.03, 3) LogUniform (0.01, 1.0E+3) LogUniform (0.01, 1.0E+3) Lognormal (1.8, 3)gonLi et al. BMC Systems Biology 2011, 5:63 http://www.biomedcentral.com/1752-0509/5/ReferenceMean (Posterior Distribution) 7.47 1.12 3.24 5.25 0.11 238 1.03 2.37 1.56E-3 79.84 175 2.88 0.12 0.027 0.012 3.95 8.86E-6 0.52 0.Median (Posterior Distribution) 7.47 1.08 1.64 4.84 0.10 138 1.01 1.83 1.53E-3 82.79 169 2.87 0.12 0.025 0.012 4.08 8.75E-6 0.51 0.95 Confidence Interval (Posterior Distribution) (5.96, 8.93) (0.71, 1.87) (0.030, 16.79) (2.29, 10.76) (0.042, 0.21) (4.23, 864) (0.93, 1.19) (1.04, 6.69) (1.15E-3, 2.12E-3) (42.61, 99.15) (121, 271) (1.97, 3.87) (0.084, 0.17) (5.73E-3, 0.065) (9.1E-3, 0.015) (2.15, 4.95) (6.29E-6, 1.20E-5) (0.38, 0.73)Partition coefficient of TB (blood to water) Dissociation constant of E2 binding to ER in brain (nmol/L) Relative binding affinity of EE2 to E2 for ER binding Relative binding affinity of TB to T for AR binding Inhibition factor for LH production by bound AR (nmol/L) PD0325901 supplement Induction factor PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27488460 for LH production by bound ER (nmol/L) Hill coefficient for T production Proportionality constant relating cholesterol to StAR Scaling coefficient of Vmax for E2 production in gonad (nmol/hr/mg micro-protein) Induction factor of E2 production by bound LH (L/nmol) Scaling coefficient of Vmax for Vtg production in liver (= Vmax/BodyWeight0.75) (nmol/hr/kg0.75) Hill coefficient of Vtg production in liver ER background production rate in liver (nmol/L/hr) Induction rate constant for ER production in liver (1/hr) AR background production rate in brain (nmol/L/hr) Inhibition factor of AR production by free androgens (nmol/L) Magnitude of LH produ.
