Ka M, Florentinus A, Williams D, Marshall JG: The endogenous peptides of standard human serum extracted from the acetonitrile-Marshall et al. Clinical Proteomics 2014, 11:3 http://www.clinicalproteomicsjournal.com/content/11/1/Page 21 ofinsoluble precipitate working with modified aqueous buffer with analysis by LC-ESI-Paul ion trap and Qq-TOF. J Proteomics 2010, 73:1254269. 64. Williams D, Ackloo S, Zhu P, Bowden P, Evans KR, Addison CL, Lock C, Marshall JG: Precipitation and selective extraction of human serum endogenous peptides with analysis by quadrupole time-of-flight mass spectrometry reveals posttranslational modifications and low-abundance peptides. Anal Bioanal Chem 2010, 396:1223247. 65. Betsou F, Gunter E, Clements J, DeSouza Y, Goddard KA, Guadagni F, Yan W, Skubitz A, Somiari S, Yeadon T, Chuaqui R: Identification of evidence-based biospecimen quality-control tools: a report with the international society for biological and environmental repositories (ISBER) biospecimen science working group. J Mol Diagn 2013, 15:36. 66. McClintock B: The stability of broken ends of chromosomes in Zea Mays. Genetics 1941, 26:23482.doi:10.1186/1559-0275-11-3 Cite this short article as: Marshall et al.: Creation of a federated database of blood proteins: a potent new tool for obtaining and characterizing biomarkers in serum. Clinical Proteomics 2014 11:3.Submit your next manuscript to BioMed Central and take complete advantage of:Practical on the web submission Thorough peer critique No space constraints or colour figure charges Immediate publication on acceptance Inclusion in PubMed, CAS, Scopus and Google Scholar Analysis which is freely available for redistributionSubmit your manuscript at www.biomedcentral.com/submit
Journal of your American Heart Association Basic SCIENCE FOR CLINICIANSAutocrine MNK2 custom synthesis Signaling in 5-HT2 Receptor Modulator Accession cardiac Remodeling: A Wealthy Supply of Therapeutic TargetsVincent F. M. Segers , MD, PhD; Gilles W. De Keulenaer , MD, PhDABSTRACT: The myocardium consists of various cell forms, of which endothelial cells, cardiomyocytes, and fibroblasts are the most abundant. Communication amongst these diverse cell types, also called paracrine signaling, is crucial for normal cardiac function, but also crucial in cardiac remodeling and heart failure. Systematic studies around the expression of ligands and their corresponding receptors in distinctive cell forms showed that for 60 of your expressed ligands in a certain cell, the receptor can also be expressed. The truth that several ligand-receptor pairs are present in most cells, which includes the key cell forms inside the heart, indicates that autocrine signaling is a widespread phenomenon. Autocrine signaling in cardiac remodeling and heart failure is involved in all pathophysiological mechanisms frequently observed: hypertrophy, fibrosis, angiogenesis, cell survival, and inflammation. Herein, we evaluation ligand-receptor pairs present within the main cardiac cell types determined by RNA-sequencing expression databases, and we critique current literature on extracellular signaling proteins with an autocrine function inside the heart; these involve C-type natriuretic peptide, fibroblast growth factors two, F21, and 23, macrophage migration inhibitory factor, heparin binding pidermal development element, angiopoietin-like protein 2, leptin, adiponectin, follistatin-like 1, apelin, neuregulin 1, vascular endothelial growth aspect, transforming growth aspect , wingless-type integration web page family members, member 1-induced secreted protein-1, interleukin 11, connective tis.
