Ash severity than placebo.42 Ziaei et al. studied the effects of vitamin E on menopausal hot flashes.43 They reported that vitamin E and placebo both decreased hot flashes, but there was a significant difference among them with regards to lowering hot flashseverity score and hot flash frequency. These results were consistent with the results with the present study. Loprinzi et al. studied the effects of venlafaxine with distinctive dosages during four weeks on 221 girls with breast cancer.44 They reported a reduction in hot flash severity scores of 31 to 61 versus 27 in placebo, in addition to a reduction in hot flash frequency of 30 to 58 versus 19 in placebo. The effects of Scitalopram compared with placebo in treating hot flash in 205 women was studied by Freeman et al.45 They discovered that Scitalopram was more helpful in decreasing hot flash severity just after eight weeks in comparison with placebo. Stearns et al. Studied the effects of paroxetine within the treatment of hot flash.46 A 62.two reduce was observed in hot flash with paroxetine with the dosage of 12.five mg along with a 64.4 decrease with the dosage of 25 mg just after six weeks of remedy, as well as a 37.eight lower by placebo. The mean day-to-day hot flash frequency with a dosage of 12.five mg decreased from 7.1 to 3.8, with a dosage of 25 mg it decreased from 6.four to 3.3, and in placebo from six.6 to four.eight. One more study around the effects of venlafaxine on hot flash of women caused by breast cancer was performed by Carpenter et al.47 This study indicated that venlafaxine was far more productive than placebo. Gordon et al. also reported that sertraline was much more helpful in decreasing hot flashes in 102 girls with menopause in comparison to placebo.48The final results of those studies are related towards the present study that is as a result of their comparable mechanism. However, the results of the study by Grady et al. indicated that sertraline was not productive on the frequency and severity of perimenopausal and postmenopausal hot flashes.49 SuvantoLuukkonen et al. cond-ucted a randomized clinical trial through 9 months on the effects of citalopram and fluoxetine on hot flashes in 150 menopausal ladies. They reported that there was no substantial difference amongst the groups concerning hot flash frequency.50 Bouchard et al. studied the effects ofJournal of GABA Receptor drug Caring Sciences, Jun 2013; two (two), 131-140|Copyright 2013 by Tabriz University of Healthcare SciencesBani et al.desvenlafaxine on vasomotor symptoms, in 35 regions of Europe, 2 regions of South Africa, and a single region of Mexico.51 In week 12 no substantial distinction was observed inside the reduction of mean frequency of everyday hot flashes between the groups. Inside the present study folic acid had no unwanted side effects; hence, it can be employed for reducing hot flashes and improving the women’s quality of life. Because you will discover a limited quantity of studies around the impact of folic acid on menopausal hot flash, further studies on this matter are encouraged.ConclusionThe results of your present study indicated that folic acid and placebo were both powerful inside the improvement of hot flash. Having said that, folic acid was more efficient. Folic acid is really a protected, affordable, and acceptable medication for ladies; hence, it can be considered as an option strategy for relieving menopausal hot flashes.Ethical issuesNone to become declared.mGluR3 manufacturer conflict of interestThe authors declare no conflict of interest within this study.AcknowledgmentsOur appreciation goes towards the investigation deputy of Tabriz University of Healthcare Sciences for the financial assistance,.