Product Name :
NAMPT inhibitor-linker 1
Description:
NAMPT inhibitor-linker 1 is a drug-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526 cells, with IC50s of <3 pM and 9 pM, respectively.
CAS:
2241019-57-6
Molecular Weight:
668.71
Formula:
C36H37FN6O6
Chemical Name:
4-(4-{3-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]propanoyl}piperazin-1-yl)-N-({2-fluoro-4-[(1S,2S)-2-(pyridin-3-yl)cyclopropaneamido]phenyl}methyl)benzamide
Smiles :
O=C(CCOCCN1C(=O)C=CC1=O)N1CCN(CC1)C1C=CC(=CC=1)C(=O)NCC1=CC=C(C=C1F)NC(=O)[C@H]1C[C@@H]1C1=CN=CC=C1
InChiKey:
ZIJGVXBDFVHKQP-IHLOFXLRSA-N
InChi :
InChI=1S/C36H37FN6O6/c37-31-20-27(40-36(48)30-21-29(30)25-2-1-12-38-22-25)6-3-26(31)23-39-35(47)24-4-7-28(8-5-24)41-13-15-42(16-14-41)32(44)11-18-49-19-17-43-33(45)9-10-34(43)46/h1-10,12,20,22,29-30H,11,13-19,21,23H2,(H,39,47)(H,40,48)/t29-,30+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Lanreotide} web|{Lanreotide} Biological Activity|{Lanreotide} Description|{Lanreotide} custom synthesis|{Lanreotide} Autophagy}
Shelf Life:
≥12 months if stored properly.{{Aliskiren} web|{Aliskiren} Metabolic Enzyme/Protease|{Aliskiren} Technical Information|{Aliskiren} Purity|{Aliskiren} custom synthesis|{Aliskiren} Epigenetics}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:35345980
Additional information:
NAMPT inhibitor-linker 1 is a drug-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526 cells, with IC50s of Product information|CAS Number: 2241019-57-6|Molecular Weight: 668.71|Formula: C36H37FN6O6|Chemical Name: 4-(4-{3-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]propanoyl}piperazin-1-yl)-N-({2-fluoro-4-[(1S,2S)-2-(pyridin-3-yl)cyclopropaneamido]phenyl}methyl)benzamide|Smiles: O=C(CCOCCN1C(=O)C=CC1=O)N1CCN(CC1)C1C=CC(=CC=1)C(=O)NCC1=CC=C(C=C1F)NC(=O)[C@H]1C[C@@H]1C1=CN=CC=C1|InChiKey: ZIJGVXBDFVHKQP-IHLOFXLRSA-N|InChi: InChI=1S/C36H37FN6O6/c37-31-20-27(40-36(48)30-21-29(30)25-2-1-12-38-22-25)6-3-26(31)23-39-35(47)24-4-7-28(8-5-24)41-13-15-42(16-14-41)32(44)11-18-49-19-17-43-33(45)9-10-34(43)46/h1-10,12,20,22,29-30H,11,13-19,21,23H2,(H,39,47)(H,40,48)/t29-,30+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ADC-3 exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of In Vivo:|ADC-3 (20 mg/kg, i.v. for 28 days) is tolerated, and causes tumor stasis in mice bearing GIST-T1 cells.|Products are for research use only. Not for human use.|
